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Poster

Session: Session 2 Presenting Authors at Posters (Odds)

P-013 - Asymmetric subspecies-selection of an immune module and reconstruction of broad-spectrum disease resistance in rice

Wednesday, July 16, 2025
13:30 - 15:15  
Location: Confex Hall 3
Crop resistance genetics and genomics

    Author(s)

  • HL

    Hui Lin

    CAS Center for Excellence in Molecular Plant Sciences
    shanghai, Shanghai, China (People's Republic)

  • FC

    Fudan Chen

    Zhejiang University
    Hangzhou, Zhejiang, China (People's Republic)

  • YD

    Yiwen Deng

    College of Agriculture and Biotechnology, Zhejiang University
    HangZhou, Zhejiang, China

  • GC

    Gongyou Chen

    Shanghai Jiaotong University
    Shanghai, Shanghai, China (People's Republic)

    • Presenting Author(s)

  • ZH

    Zuhua He

    Professor
    CAS Center for Excellence in Molecular Plant Sciences, CAS
    Shanghai, CHINA

Artificial selection has greatly shaped the genomes and agronomic traits of crops; however, the mechanistic basis of plant immunity selection has remained elusive. This study identifies the rice NLR receptor XA48 that forms an immune module with its downstream transcription factor (TF) OsVOZ, and confers resistance to bacterial blight. XA48 perceives the ancient pathogen effector, XopG, to activates effector-triggered immunity (ETI), which shows an agroecological distribution of Asian rice regions. The XA48-OsVOZ1 module has undergone subspecies-specific artificial selection. The functional Xa48 has been retained in indica but lost in japonica rice, while OsVOZ1 has diverged into two subspecies haplotypes. Xa48 greatly decreased japonica reproduction when combined with the japonica OsVOZ1A allele but not OsVOZ1S that exists only in indica, explaining the loss of Xa48 in japonica. We resurrected broad-spectrum resistance by stacking XA48 with XA21, which elicit ETI and pattern-triggered immunity (PTI), respectively. Our study reveals that the asymmetric selection of an NLR-TF module shapes both disease resistance and reproduction and also provides a paradigm for breeding crops by harnessing the immunity of wild relatives.