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Poster

Session: Session 2 Presenting Authors at Posters (Evens)

P-124 - Effector-triggered processing body formation attenuates host translation to dampen plant immunity upon infection

Thursday, July 17, 2025
13:30 - 15:15  
Location: Confex Hall 3
Effector Interference Mechanisms

    Presenting Author(s)

  • MG

    Manuel Gonzalez Fuente

    Faculty of Biology and Biotechnology, Ruhr-University of Bochum
    Bochum, Nordrhein-Westfalen, Germany

    • Author(s)

  • NS

    Nico Schulz

    Faculty of Biology and Biotechnology, Ruhr-University of Bochum
    Bochum, Nordrhein-Westfalen, Germany

  • AA

    Alibek Abdrakhmanov

    Gregor Mendel Institute (GMI), Austrian Academy of Sciences
    Vienna, Wien, Austria

  • SZ

    Shanshuo Zhu

    Faculty of Biology and Biotechnology, Ruhr-University of Bochum
    Bochum, Nordrhein-Westfalen, Germany

  • GL

    Gautier Langin

    Faculty of Biology and Biotechnology, Ruhr-University of Bochum
    Bochum, Nordrhein-Westfalen, Germany

  • MF

    Mirita Franz-Wachtel

    Proteome Center Tübingen, University of Tübingen
    Tübingen, Baden-Wurttemberg, Germany

  • BM

    Boris Macek

    Proteome Center Tübingen, University of Tübingen
    Tübingen, Baden-Wurttemberg, Germany

  • AH

    Anders Hafren

    Department of Plant Biology, Swedish University of Agricultural Sciences
    Uppsala, Uppsala Lan, Sweden

  • YD

    Yasin Dagdas

    The Gregor Mendel Institute of Molecular Plant Biology
    Vienna, Wien, Austria

  • SÃ

    Suayib Üstün

    Faculty of Biology and Biotechnology, Ruhr-University of Bochum
    Bochum, Nordrhein-Westfalen, Germany

Abstract Text:

Compartmentalization of transcripts into biomolecular condensates allows quick responses to environmental cues. Processing bodies (P-bodies) are cytosolic ribonucleoprotein aggregates that regulate different developmental processes and stress responses. Pathogens, in their effort to modulate their host protein homeostasis, have developed intricate mechanisms to exploit proteolytic pathways, however whether and how the modulate protein synthesis remains elusive. We show that phytopathogenic bacteria Pseudomonas syringae pv. tomato (Pst) induces the assembly of P-bodies through two different effectors, evidencing P-bodies as novel susceptibility hubs. Pst infection is also marked by general attenuation of the plant translation in an effector- and P-body-dependent manner. Furthermore, we discovered that autophagy and repression of the ER stress response are both required for the Pst-mediated enhanced assembly of P-bodies and translational attenuation. Taken together, our work sheds light into how bacteria modulate the host translation to dampen plant immunity and reveals a new interplay between the ER stress response, autophagy and P-bodies in the context of plant-pathogen interactions.