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Concurrent Session

Session: Concurrent Session: Extracellular & Intracellular non-self recognition & signaling (1)

Engineering Plant Immunity by Leveraging Kinase-Mediated Defense Responses

Monday, July 14, 2025
15:55 - 16:15  
Location: Room M+N

Plants rely on kinases for receptor activation, immune signaling, and defense responses. The intracellular tandem kinase RWT4 acts as a pathogen sensor, directly binding the PWT4 effector primarily through an integrated kinase duplication. Surface-localized receptor kinases can detect pathogens, damage, and danger, while intracellular tandem kinases can bind effectors and connect to canonical immune receptors. The receptor kinase FLS2 perceives bacterial flagellin, but most homologs exhibit narrow recognition of flg22 epitopes. By mapping key residues on FLS2’s inner concave surface, we identified determinants of expanded recognition and engineered synthetic receptors with broader pathogen detection.  Together, these findings illustrate how mechanistic insights into kinase-mediated recognition and signaling can be leveraged to enhance plant immunity.