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Poster

Session: Session 2 Presenting Authors at Posters (Odds)

P-095 - Plant microbiota feedbacks through dose-responsive expression of general non-self response genes

Wednesday, July 16, 2025
13:30 - 15:15  
Location: Confex Hall 3
Discrimination of friend from foe


Plants continuously perceive and respond to diverse environmental stresses to maintain health. We previously identified a set of plant ‘general non-self response’ (GNSR) genes that are induced upon colonization by leaf microbiota members. Several GNSR genes are involved in the biosynthesis of defense compounds and contribute to protection against pathogens. However, whether these microbiota-responsive genes shaped interactions with the microbiota remained elusive. Here, we employed a synthetic community approach and found that the GNSR impacts leaf microbiota assembly. Bacterial strains that benefited from the absence of GNSR genes were strong plant response inducers, revealing a dynamic modulation of bacterial leaf colonization. Using live and inactivated bacteria, we show that the host response intensity is determined collectively by bacterial abundance, cellular composition, and exposure time. Our findings position the GNSR as an integral part of pattern-triggered immunity, with diverse immunogenic elicitors causing dynamic GNSR gene expression. Our research indicates a dose-responsive signaling system underlying the GNSR that modulates the microbiota and contributes to plant-microbiome homeostasis.