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Poster

Session: Session 2 Presenting Authors at Posters (Odds)

P-257 - Pseudomonas alter the host chemical environment to invade host tissues

Wednesday, July 16, 2025
13:30 - 15:15  
Location: Confex Hall 3
Nutrient exchange & role of metabolites in plant-microbe interactions
A pathogen’s ability to colonize a plant is in part determined by the defensive secondary metabolites produced by their plant hosts. To understand host-specific interactions, we will need to determine which plant secondary metabolites are effective against which microbes. We aim to understand how glucosinolates, a type of secondary metabolite nearly exclusive to the Brassicaceae, and one toxic product of glucosinolate hydrolysis, isothiocyanates, have shaped the co-evolution of Brassicaceae plants and the pathogens that colonize them. First, we have found that plants alter glucosinolate profiles based on what pathogen is infecting them. Using individual compound assays, we have determined that a clade of Pseudomonas that specializes on Brassicaceae is highly resistant to a variety of isothiocyanates. Gas chromatography-mass spectrometry analysis of these samples has demonstrated this clade is actively metabolizing the isothiocyanates. Overall, our results demonstrate that Brassicaceae-associated pseudomonads are efficient at detoxifying their surrounding environment of these Brassicaceae-specific compounds. This may represent a key adaptation for these strains to successfully colonize Brassicaceae.