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Poster

Session: Session 2 Presenting Authors at Posters (Odds)

P-301 - A TNL receptor mediates microbiome feedbacks in Arabidopsis thaliana

Wednesday, July 16, 2025
13:30 - 15:15  
Location: Confex Hall 3
Plant microbiota functions and intermicrobial interactions

Plant performance depends on the qualitative and quantitative composition of the soil microbiome. While microbiome feedbacks on the host plant are well documented, the mechanisms by which plants perceive and mediate these feedbacks remain unclear. Here, we used maize plants to condition two different soil microbiomes in the same soil type. Depending on the release of benzoxazinoids by the plant, the resulting microbiomes have been shown previously to differentially affect plant growth in subsequent plantings. We established a framework using these two distinct microbiomes to investigate the genetic basis of microbiome feedbacks by screening the growth of 410 Arabidopsis thaliana accessions. Using the substantial variation in growth feedbacks as a phenotype in genome-wide association mapping, we identified the immune receptor Mediator of Microbiome Feedback 1 (MMF1). Characterisation in the reference accession Col-0 revealed that mmf1 loss-of-function mutants lacked the differential growth feedbacks in response to the two microbiomes, had an altered root bacterial community, and failed to induce a defence-related transcriptional response observed in wild-type plants. The discovery of MMF1 implies that integration of microbial effector signals optimises host microbiome composition and immune status to enhance growth.