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Poster

Session: Session 1 Presenting Authors at Posters (Evens)

P-384 - Regulation of the ion channel-like protein ACD6 via small proteins to fine-tune immune regulation in Arabidopsis thaliana

Tuesday, July 15, 2025
09:55 - 11:30  
Location: Confex Hall 3
Subcellular dynamics and signaling in host-microbe interactions

    Presenting Author(s)

  • JK

    Jong Hum Kim

    Pohang University of Science and Technology
    Pohang, Kyongsang-bukto, Republic of Korea

    • Author(s)

  • DW

    Detlef Weigel

    Max Planck Institute for Biology
    Tübingen, Baden-Wurttemberg, Germany

  • WZ

    Wangsheng Zhu

    China agricultural university
    Beijing, Beijing, China (People's Republic)

This study investigates the transmembrane protein ACCELERATED CELL DEATH 6 (ACD6), an immune regulator in Arabidopsis thaliana whose biochemical mechanism remains unclear. Genetic screening aimed at identifying new regulators of ACD6 revealed two loci: MODULATOR OF HYPERACTIVE ACD6 1 (MHA1) and its paralog MHA1-LIKE (MHA1L). These loci encode proteins of approximately 7 kDa that interact with distinct ACD6 variants in different ways. MHA1L promotes the accumulation of an ACD6 complex, boosting the activity of the standard ACD6 allele, which regulates plant growth and defense responses. The intracellular ankyrin repeats of ACD6 share structural features with those in mammalian ion channels. Evidence suggests a link between increased ACD6 activity and enhanced calcium influx, with MHA1L acting as a direct regulator.