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Poster

Session: Session 2 Presenting Authors at Posters (Odds)

P-445 - Spatial and temporal dynamics of endogenous giant virus activation in Ectocarpus

Wednesday, July 16, 2025
13:30 - 15:15  
Location: Confex Hall 3
Spatial & temporal resolution of the interaction interface

    Presenting Author(s)

  • LW

    Liping Wang

    Max Planck Institute for Biology Tübingen
    Tübingen, Tübingen, GERMANY

    • Author(s)

  • CM

    Claudia Martinho

    Max Planck Institute for Biology Tübingen
    Tübingen, Baden-Wurttemberg, Germany

  • PL

    Pengfei Liu

    MPI for Biology Tuebingen
    Tübingen, Baden-Wurttemberg, Germany

  • JL

    Jaruwatana Lotharukpong

    Max Planck Institute for Biology Tübingen
    Tübingen, Baden-Wurttemberg, Germany

  • CD

    Carole Duchene

    Max Planck Institute for Biology Tübingen
    Tübingen, Baden-Wurttemberg, Germany

  • MZ

    Min Zheng

    Max Planck Institute for Biology Tübingen
    Tübingen, Baden-Wurttemberg, Germany

  • RL

    Remy Luthringer

    Max Planck Institute for Biology Tübingen
    Tübingen, Baden-Wurttemberg, Germany

  • FH

    Fabian Haas

    Max Planck Institute for Biology Tübingen
    Tübingen, Baden-Wurttemberg, Germany

  • SC

    Susana Coelho

    Max Planck Institute for Biology Tübingen
    Tübingen, Baden-Wurttemberg, Germany

Genome sequencing is increasingly uncovering integrated viral DNA within the genomes of various eukaryotes. Some eukaryotic viruses are lysogenic, and their persistent integration into the host genome is a fundamental part of their life cycle. This is notably seen in phaeoviruses, which infect brown algae and are distinguished by their large genomes, often spanning several hundred kilobases and containing hundreds of genes. The life cycle of these 'giant' phaeoviruses is intricately coordinated with the reproductive cycle of their hosts, Previous studies have identified endogenous viral elements (EVEs) in the model brown alga Ectocarpus genome, with sequences closely related to Ectocarpus siliculosus Virus-1 (EsV-1). While some EVEs are transcriptionally silent, we identified an active EVE that is transcriptionally active and induces symptoms that are spatially restricted to reproductive tissues. The reasons behind this restricted viral proliferation and the cell-type specific response during virus-algae interactions have remained elusive. Here, we employed single-nuclei RNA sequencing combined with RNA-FISH to investigate the dynamics and cell-type specific interactions of the host-virus relationship. Our findings provide insights into the molecular mechanisms underlying these interactions, advancing our understanding of host-pathogen dynamics in brown algae.