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Poster

Session: Session 2 Presenting Authors at Posters (Evens)

P-100 - A nonclassically secreted effector of Magnaporthe oryzae targets host nuclei and regulates the rice immunity

Thursday, July 17, 2025
13:30 - 15:15  
Location: Confex Hall 3
Effector Interference Mechanisms

    Presenting Author(s)

  • ZW

    Zonghua Wang

    Professor
    Institute of Oceanography, Minjiang University
    Fuzhou, Fujian, China (People's Republic)

    • Author(s)

  • XC

    Xiaomin Chen

    Dr.
    2.College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
    Fuzhou, Fujian, China (People's Republic)

  • WT

    Wei Tang

    College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
    Fuzhou, Fujian, China (People's Republic)

  • JF

    Jiaxin Fan

    College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
    Fuzhou, Fujian, China (People's Republic)

Rice blast disease, caused by Magnaporthe oryzae, is one of the most destructive diseases and poses a significant threat to global food security. To facilitate host colonization, M. oryzae secretes variety of effector proteins to suppress host defense responses. However, most characterized effectors contain an N-terminal signal peptide, and knowledge about the nuclear-targeting effectors remain limited. Here, we characterize MoNte1 as a nucleus-targeting effector, which lacks an N-terminal signal peptide, but is required for the pathogenicity of M. oryzae. To promote host infection, MoNte1 targets rice cinnamyl alcohol dehydrogenase 8B (OsCad8B), disrupting its distribution and enzyme activity, thereby suppressing PAMP-triggered immunity. Our findings provide novel insights into the roles of nuclear-targeting effector that M. oryzae employs to promote host colonization.