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Poster

Session: Session 1 Presenting Authors at Posters (Evens)

P-100 - Unraveling the molecular basis of plant immunity priming by bacterial cyclic lipopeptides

Tuesday, July 15, 2025
09:55 - 11:30  
Location: Confex Hall 3
Extracellular & Intracellular non-self recognition & signaling
The root‑associated bacterium Bacillus velezensis has been demonstrated to protect plants against diseases by triggering induced resistance. A crucial component of this process is surfactin, a bioactive secondary metabolite secreted by B. velezensis. Upon recognition by the plant, this compound induces a primed state, enhancing the plant’s ability to mount a rapid defense response upon subsequent pathogen attacks. Previous research revealed that surfactin is not recognized in the canonical way as a microbial‑associated molecular pattern by the plant’s pattern recognition receptors. Consequently, it does not trigger induced resistance through the conventional pattern‑triggered immunity pathway. Instead, it interacts directly with the plant cell plasma membrane, leading to unusually rapid immune responses and priming of the plant. To unravel the molecular basis of surfactin recognition and the resultant primed state, we used single‑cell RNA sequencing in Arabidopsis thaliana roots to capture cell‑type‑specific responses. Additionally, we are conducting disease assays with Botrytis cinerea, Pseudomonas syringae, and Hyaloperonospora arabidopsidis, followed by transcriptomic and metabolomic analyses in the leaves to assess systemic effects. Integrating these data will reveal key pathways in surfactin-induced priming, advancing our understanding of immune priming mechanisms and contributing to sustainable crop protection strategies.