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Poster

Session: Session 1 Presenting Authors at Posters (Evens)

P-104 - A natural cyclic peptide valinomycin enhances plant resistance by immune-priming

Tuesday, July 15, 2025
09:55 - 11:30  
Location: Confex Hall 3
Management of diseases and emerging diseases

    Presenting Author(s)

  • NY

    Nayeon Yoo

    Korea Univ
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

    • Author(s)

  • JK

    Ji Eun Kang

    Michigan State University
    East Lansing, Michigan, United States

  • DK

    Daran Kim

    Gyeongsang National University
    Jinju, Kyongsang-namdo, Republic of Korea

  • SK

    Sumin Kim

    Korea Univ
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • SK

    Sungjun Kim

    Korea Univ
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • YL

    Yae-Eun Lee

    Korea Univ
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • KL

    Kangtoe Lee

    Korea Univ
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • MS

    Mee Kyung Sang

    National Institute of Agricultural Sciences
    Wanju, Cholla-bukto, Republic of Korea

  • YK

    Youn-Sig Kwak

    Gyeongsang National University
    Jinju, Kyongsang-namdo, Republic of Korea

  • EC

    Eui-Hwan Chung

    Korea University
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

The intensive research has led to the identification of various natural compounds as alternative agents for the chemical management of plant diseases. Here, we propose that valinomycin, a cyclic peptide produced by Streptomyces bacillaris S8, is a putative multifunctional biocontrol agent against various plant pathogens. The compound acts as an antifungal agent against several plant pathogenic fungi, including Botrytis cinerea, a necrotroph that causes gray mold. Intriguingly, valinomycin can also boost plant immunity with priming activity in response to pathogen infection. Valinomycin-treated plants demonstrated increased flg22-mediated ROS burst, MAPK phosphorylation, and callose deposition, hallmarks of PAMPs-triggered immunity (PTI). Regarding effector-triggered immunity (ETI), valinomycin potentiated hypersensitive response, a representative phenotype of the ETI responses. Furthermore, ROS burst assay revealed that valinomycin simultaneously facilitates PTI and ETI that mutually strengthen each other. Both locally and systemically, valinomycin could enhance the resistance against Pseudomonas syringae pv. tomato DC3000, without direct antibacterial activity. Transcriptional analysis indicated that valinomycin treatment upregulated salicylic acid-related genes, while downregulating jasmonic acid-related genes. Therefore, our study demonstrates that valinomycin harbors potential as a biocontrol agent suppressing complex pathogen infections with versatile functions.