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Poster

Session: Session 1 Presenting Authors at Posters (Odds)

P-031 - Elucidation of a perception mechanism for cell wall-derived oligogalacturonides in Arabidopsis thaliana

Monday, July 14, 2025
13:30 - 15:15  
Location: Confex Hall 3
Extracellular & Intracellular non-self recognition & signaling

    Presenting Author(s)

  • JO

    Jana Ordon, PhD

    Postdoctoral Researcher
    University of Zurich
    Zurich, Zurich, Switzerland

    • Author(s)

  • OK

    Owen Kentish

    University of Lausanne
    Lausanne, Vaud, Switzerland

  • KC

    Klara Culjak

    Centro de Biotecnología y Genómica de Plantas (CBGP), Centro Severo Ochoa, Universidad Politécnica de Madrid (UPM) – Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA/CSIC)
    Madrid, Madrid, SPAIN

  • KB

    Kyle W. Bender

    Institute of Plant and Microbial Biology, University of Zurich
    Zurich, Zurich, Switzerland

  • MM

    Marina Martín-Dacal

    Centro de Biotecnología y Genómica de Plantas (CBGP), Centro Severo Ochoa, Universidad Politécnica de Madrid (UPM) – Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA/CSIC)
    Madrid, Madrid, Spain

  • MT

    Miguel Ángel Torres

    Associate Professor
    Centro de Biotecnología y Genómica de Plantas (CBGP), Centro Severo Ochoa, Universidad Politécnica de Madrid (UPM) – Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA/CSIC)
    Madrid, Madrid, Spain

  • LJ

    Lucia Jorda, PhD (she/her/hers)

    Associate Professor
    Centro de Biotecnología y Genómica de Plantas (CBGP), Centro Severo Ochoa, Universidad Politécnica de Madrid (UPM) – Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA/CSIC)
    Pozuelo de Alarcon, Madrid, Spain

  • JS

    Julia Santiago

    University of Lausanne
    Lausanne, Vaud, Switzerland

  • AM

    Antonio Molina

    Full Professor
    Centro de Biotecnología y Genómica de Plantas (CBGP), Centro Severo Ochoa, Universidad Politécnica de Madrid (UPM) – Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA/CSIC)
    Madrid, Madrid, Spain

  • CZ

    Cyril Zipfel

    Institute of Plant and Microbial Biology, University of Zurich / The Sainsbury Laboratory
    Zurich, Zurich, Switzerland

Cell wall-derived oligogalacturonides (OGs) function as damage-associated molecular patterns and induce plant immune responses. Pectin-binding receptor kinases (RKs) of the WALL-ASSOCIATED KINASE (WAK) family were previously proposed as OG receptors. However, we recently showed that an Arabidopsis thaliana mutant lacking all five WAK genes exhibits wild type-like hallmarks of immune responses upon OG treatment. Thus, bona fide OG receptors remain still to be identified. Here we report an Arabidopsis RK associated with OG perception. Mutants of this RK are impaired in early OG-induced responses, including Ca2+ influx, mitogen-associated protein kinase activation, and immune marker gene expression. These mutants also exhibited increased susceptibility to hemi-biotrophic and necrotrophic but not obligate biotrophic pathogens. While early responses induced by OG treatment were strongly impaired or abolished, long-term immune responses were partially retained in the mutants, suggesting that this RK does not function alone. Notably, using a recently established untargeted quantitative phosphoproteomics workflow, we identified a related RK that is specifically phosphorylated on its activation loop upon OG treatment, suggesting receptor activation. Thus, we hypothesize that multiple members of this RK family function in concert during OG perception, as part of a cell wall integrity surveillance system that acts against disruptive pathogens.