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Poster

Session: Session 1 Presenting Authors at Posters (Odds)

P-049 - Investigating proteolytic processing as a mechanism of regulation of the function of cell surface immune receptors

Monday, July 14, 2025
13:30 - 15:15  
Location: Confex Hall 3
Extracellular & Intracellular non-self recognition & signaling

    Author(s)

  • AA

    Adithya Acharya

    PhD student
    Leibniz Institute of Plant Biochemistry
    Halle (Saale), Sachsen-Anhalt, Germany

  • BO

    Birgit Ortel

    Leibniz Institute of Plant Biochemistry
    Halle (Saale), Sachsen-Anhalt, Germany

  • AB

    Anna Bannmüller

    PhD student
    Leibniz Institute of Plant Biochemistry
    Halle, Sachsen-Anhalt, Germany

  • SM

    Susanne Matschi

    Postdoc
    Leibniz-Institute of Plant Biochemistry
    Halle, Sachsen-Anhalt, Germany

  • MR

    Martina Ried-Lasi

    Leibniz Institute of Plant Biochemistry
    Halle (Saale), Sachsen-Anhalt, Germany

    • Presenting Author(s)

  • MS

    Mariana Schuster, PhD (she/her/hers)

    Group Leader
    Leibniz Institute of Plant Biochemistry
    Halle, Sachsen-Anhalt, Germany

Plants perceive pathogens through receptor proteins, many of which reside in the plasma membrane. The regulation of the function of these receptors is governed by complex formation and post translational modifications including proteolytic processing. Proteolytic processing of immune receptors has been documented a handful of times but the consequences of cleavage as well as the proteases involved in this process remain mostly unknown. We have shown that at least 13 immune receptor-like kinases (RLKs) undergo proteolytic processing in the model plant Nicotiana benthamiana. In all cases, processing releases the ectodomain which suggests the prevalence of ectodomain shedding as a regulation mechanism of membrane-bound receptors in plants. We are investigating the functional consequences of immune receptor processing as well as identifying the corresponding sheddases.