Skip to main content
ISMPMI Congress 2025 Main banner
Icon Legend
This session is not in your schedule.
This session is in your schedule. Click again to remove it.

Poster

Session: Session 1 Presenting Authors at Posters (Odds)

P-061 - Novel genes involved in Zinc-mediated immunity in Arabidopsis thaliana

Monday, July 14, 2025
13:30 - 15:15  
Location: Confex Hall 3
Extracellular & Intracellular non-self recognition & signaling

    Presenting Author(s)

  • AA

    Alejandro Manuel Armas

    CBGP (UPM-INIA/CSIC)
    Madrid, Madrid, Spain

    • Author(s)

  • VE

    Viviana Escudero

    CBGP (UPM-INIA/CSIC)
    Madrid, Madrid, Spain

  • CH

    Cuong Hoang, PhD

    CBGP (UPM-INIA/CSIC)
    Riverside, California, United States

  • AG

    Antoni García-Molina

    Centre for Research in Agricultural Genomics (CRAG)
    Barcelona, Catalonia, Spain

  • MG

    María Garrido-Arandia

    Centro de Biotecnología y Genómica de Plantas (CBGP), Universidad Politécnica de Madrid (UPM)- Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA/CSIC), Madrid, Spain; Departamento de Biotecnología-Biología Vegetal, Escuela Técnica Superior de Ingeniería Agronómica, Alimentaria y de Biosistemas, Universidad Politécnica de Madrid (UPM), Madrid, Spain
    Madrid, Madrid, Spain

  • GV

    Gonzalo Vílchez-Pinto

    Centro de Biotecnología y Genómica de Plantas (CBGP), Universidad Politécnica de Madrid (UPM)- Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA/CSIC), Madrid, Spain; Departamento de Biotecnología-Biología Vegetal, Escuela Técnica Superior de Ingeniería Agronómica, Alimentaria y de Biosistemas, Universidad Politécnica de Madrid (UPM), Madrid, Spain
    Madrid, Madrid, Spain

  • MG

    Manuel González-Guerrero

    CBGP (UPM-INIA/CSIC) Departamento de Biotecnología-Biología Vegetal, Escuela Técnica Superior de Ingeniería Agronómica, Alimentaria y de Biosistemas
    Madrid, Madrid, Spain

  • LJ

    Lucia Jorda, PhD (she/her/hers)

    Associate Professor
    Centro de Biotecnología y Genómica de Plantas (CBGP), Centro Severo Ochoa, Universidad Politécnica de Madrid (UPM) – Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA/CSIC)
    Pozuelo de Alarcon, Madrid, Spain

Zinc (Zn) has a very narrow biological range. While low concentrations lead to severe physiological alterations, slightly higher levels are toxic. This double-edged aspect of Zn is used by plants to combat pathogen attacks. Our lab has recently shown that Arabidopsis thaliana Zn2+-transporting ATPases HMA2 and HMA4 are involved in Zinc-mediated immunity (ZiMI). By locally increasing Zn concentration at the infection site of the necrotrophic fungus Plectosphaerella cucumerina BMM (PcBMM), HMA2 and HMA4 control fungal proliferation. When these two genes are mutated, the plant becomes more susceptible. From RNAseq analyses comparing the combined transcriptional responses to PcBMM infection and to hma2hma4 mutation, we identified 15 genes that could be involved in ZiMI. Analyses of the mutants of these genes have shown that two of them, dob5 and grp, have altered susceptibility to PcBMM. Through protein modelling, another one, a HIPP-family member, has been proposed as an interactor of HMA2. The interaction would take place at the “platform” of the ATPase, in a place in which Zn would be transferred to HMA2 transmembrane metal binding sites. Consistent with a role of HIPP as a metal donor, Zn binding was confirmed. Future studies will be directed towards unveiling the molecular bases of DOB5 and GRP action, as well as determining Zn transfer from HIPP to HMA2.