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Poster

Session: Session 1 Presenting Authors at Posters (Odds)

P-015 - Cell Surface-mediated immunity activates an intracellular NLR receptor alternative splicing

Monday, July 14, 2025
13:30 - 15:15  
Location: Confex Hall 3
Extracellular & Intracellular non-self recognition & signaling

    Author(s)

  • CG

    Chuyun Gao

    Nanjing Agricultural University
    Nanjing, Jiangsu, China (People's Republic)

    • Presenting Author(s)

  • XM

    Xi Meng

    Nanjing Agricultural University
    Nanjing, CHINA, CHINA

    • Author(s)

  • XC

    Xianchu Chen

    Nanjing Agricultural University
    Nanjing, Jiangsu, China (People's Republic)

  • KL

    Kangping Li

    Nanjing Agricultural University
    Nanjing, Jiangsu, China (People's Republic)

  • BS

    Biying Sun

    Nanjing Agricultural University
    Nanjing, Jiangsu, China (People's Republic)

  • AT

    AmirAli Toghani (he/him/his)

    PhD Student
    The Sainsbury Laboratory
    Norwich, England, United Kingdom

  • LW

    Luyao Wang

    Nanjing Agricultural University
    Nanjing, Jiangsu, China (People's Republic)

  • YW

    Yuanchao Wang

    Nanjing Agricultural University
    Nanjing, Jiangsu, China (People's Republic)

  • LY

    Leiyun Yang

    Nanjing Agricultural University
    Nanjing, Jiangsu, China (People's Republic)

  • TB

    Tolga Bozkurt, PhD (he/him/his)

    Reader
    Imperial College London
    London, England, United Kingdom

  • SK

    Sophien Kamoun

    Group leader
    The Sainsbury Laboratory
    Norwich, England, United Kingdom

  • SD

    Suomeng Dong

    Nanjing Agricultural University
    Nanjing, Jiangsu, China (People's Republic)

Plants had evolved a robust immune system to defeat invading pathogens. Two layers of the plant immunity are in general the cell surface receptor-mediated PTI (PAMP triggered immunity) and intracellular NLR receptor-mediated ETI (effector triggered immunity). Recent evidence suggests these two layers of immunity mutually potentiate the other, however, the molecular mechanisms of their cross-talk remain largely unknown. Potato late blight is a notorious plant disease caused by Phytophthora infestans. This pathogen delivers apoplastic effector to trigger PTI and cytoplasmic effector to activate ETI, respectively. Our latest study shows that PTI enhances Rpi-vnt1.1 (a CC type-NLR) -mediated ETI response. Investigation revealed that PTI promotes RNA alternative splicing of the Rpi-vnt1.1 transcript, resulting in the increased abundance of matured NLR protein that are ready for resistosome assembly. Our findings elucidate a mechanism through which plant PTI potentiates ETI, thereby providing an insight into the regulatory network of robust plant immune system.