Skip to main content
ISMPMI Congress 2025 Main banner
Icon Legend
This session is not in your schedule.
This session is in your schedule. Click again to remove it.

Concurrent Session

Session: Concurrent Session: Crop resistance genetics and genomics

A canonical protein complex controls immune homeostasis and multipathogen resistance in rice

Wednesday, July 16, 2025
16:15 - 16:25  
Location: Room M+N

    Author(s)

  • YW

    Yue Wu

    CAS Center for Excellence in Molecular Plant Sciences
    Shanghai, CHINA

    • Author(s)

  • WX

    Weiying Xu

    CAS Center for Excellence in Molecular Plant Sciences
    Shanghai, Shanghai, China (People's Republic)

  • YD

    Yiwen Deng

    College of Agriculture and Biotechnology, Zhejiang University
    HangZhou, Zhejiang, China

  • MG

    Mingjun Gao

    School of Life Sciences, Fudan University
    Shanghai, Shanghai, China (People's Republic)

  • JP

    Jane Parker

    Senior Group Leader
    Department of Plant-Microbe Interactions, Max-Planck Institute for Plant Breeding Research
    Cologne, GERMANY

  • YZ

    Yu Zhang

    PI
    CAS Center for Excellence in Molecular Plant Sciences
    Shanghai, Shanghai, China (People's Republic)

    • Presenting Author(s)

  • ZH

    Zuhua He

    Professor
    CAS Center for Excellence in Molecular Plant Sciences, CAS
    Shanghai, CHINA

Abstract Text:

The calcium (Ca2+) sensor ROD1 (RESISTANCE OF RICE TO DISEASES1) is a master regulator of immunity in rice. By screening suppressors of rod1 mutants, we show that ROD1 governs immune homeostasis by surveilling the activation of a canonical immune pathway. Mutations in OsTIR (TIR-only protein), OsEDS1 (enhanced disease susceptibility 1), OsPAD4 (phytoalexin deficient 4), and OsADR1 (activated disease resistance 1) all abolish enhanced disease resistance of rod1 plants. OsTIR catalyzes the production of second messengers 2′-(5″-phosphoribosyl)-5′-adenosine monophosphate (pRib-AMP) and diphosphate (pRib-ADP), which trigger formation of an OsEDS1-OsPAD4-OsADR1 (EPA) immune complex. ROD1 interacts with OsTIR and inhibits its enzymatic activity, whereas mutation of ROD1 leads to constitutive activation of the EPA complex. Thus, we unveil an immune network that fine-tunes immune homeostasis and multipathogen resistance in rice.