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Concurrent Session

Session: Concurrent Session: Plant Interactions with nematodes & parasitic plants

A trehalase-derived MAMP triggers LecRK-V-mediated immune responses in Arabidopsis

Wednesday, July 16, 2025
10:50 - 11:10  
Location: Room P+Q

Plant-parasitic nematodes (PPNs) cause major agricultural losses worldwide, yet the molecular basis of plant immunity against these pathogens remains poorly understood. To investigate how plants recognize PPNs, we aimed to identify microbe-associated molecular patterns (MAMPs) from nematodes and the corresponding plant immune components. Due to the limited availability of material from obligate PPNs, we used Caenorhabditis elegans, a free-living nematode, as a MAMP source. C. elegans extracts activated MAMP-triggered immune responses in Arabidopsis thaliana Col-0, leading us to purify immunogenic factors using chromatography. We identified a secreted trehalase and pinpointed a conserved peptide region shared between C. elegans and PPNs that is essential for its MAMP activity. A corresponding peptide from root-knot nematode trehalase, along with the insensitive Arabidopsis accession Cvi-0, facilitated the identification of lectin receptor kinases LecRK-V.5 and LecRK-V.6 as key immune components. Notably, this peptide region is conserved across insect and fungal pathogens, and LecRK-Vs are required for immune activation in response to these peptides, suggesting that LecRK-V-mediated signaling contributes to broad-spectrum pathogen detection via trehalase-derived peptides.