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Plenary Session

Session: Opening Keynote and Plenary Session 1

TIR catalyzed signals at the heart of plant immunity

Sunday, July 13, 2025
16:20 - 16:45  
Location: Confex Hall 1+2

    Speaker(s)

  • JP

    Jane Parker

    Senior Group Leader
    Department of Plant-Microbe Interactions, Max-Planck Institute for Plant Breeding Research
    Cologne, GERMANY

    • Author(s)

  • JW

    Junli Wang

    Postd
    Max Planck Institute for Plant Breeding Research, Germany
    Cologne, Nordrhein-Westfalen, Germany

  • SH

    Shijia Huang

    Westlake Institute for Advanced Study
    Hangzhou, Zhejiang, China (People's Republic)

  • FL

    Federica Locci

    Postdoc
    Max Planck Institute for Plant Breeding Research
    Koln, Nordrhein-Westfalen, Germany

  • HL

    Henriette Lässle

    Department of Plant-Microbe Interactions, Max-Planck Institute for Plant Breeding Research
    Koln, Nordrhein-Westfalen, Germany

  • LZ

    Lisha Zhang

    Dr
    University of Tübingen
    Tuebingen, Baden-Wurttemberg, Germany

  • TN

    Thorsten Nürnberger

    University of Tübingen
    Tuebingen, Baden-Wurttemberg, Germany

  • DL

    Dmitry Lapin (he/him/his)

    Group Leader
    Utrecht University
    Utrecht, Utrecht, Netherlands

  • YW

    Yue Wu

    CAS Center for Excellence in Molecular Plant Sciences
    Shanghai, CHINA

  • ZH

    Zuhua He

    Professor
    CAS Center for Excellence in Molecular Plant Sciences, CAS
    Shanghai, CHINA

  • JC

    Jijie Chai

    Professor
    Westlake University
    Hangzhou, Zhejiang, China (People's Republic)

Many components of plant and mammalian innate immunity have bacterial origins. Useful domains have, in the course of evolution, been selected, assembled and reassembled into functional modules for resistance to microbial infection. The Toll-Interleukin1-Receptor (TIR) domain is one such protein unit with important immunity functions across cellular kingdoms. I will discuss recent mechanistic insights into plant TIR-domain proteins which catalyze the production of nucleotide messengers regulating host defense and cell death. TIR-domain containing NLR receptors (called TNLs) recognizing specific pathogen effectors inside cells, as well as suites of smaller immune-responsive TIR-domain (TIR-NB and TIR-only) mobilized by cell-surface pattern recognition receptors (PRRs), signal via their TIR catalytic products converging on canonical machineries for immunity execution. Collective genetic, phylogenomic, biochemical and structural studies reveal the centrality of TIR enzyme-regulated immune responses in dicot and monocot plants.